abstract：:The concentration of CXCL12/SDF-1 in the bloodstream is tightly regulated, given its central role in leucocyte and stem/progenitor cell egress from bone marrow and recruitment to sites of inflammation or injury. The mechanism responsible for this regulation is unknown. Here we show that both genetic deletion and pharm...

journal_title：Immunology

authors： Berahovich RD,Zabel BA,Lewén S,Walters MJ,Ebsworth K,Wang Y,Jaen JC,Schall TJ

更新日期：2014-01-01 00:00:00

abstract：:Variation in the sequence of T-cell epitopes between dengue virus (DENV) serotypes is believed to alter memory T-cell responses during second heterologous infections. We identified a highly conserved, novel, HLA-B57-restricted epitope on the DENV NS1 protein. We predicted higher frequencies of B57-NS1(26-34) -specific...

journal_title：Immunology

authors： Townsley E,Woda M,Thomas SJ,Kalayanarooj S,Gibbons RV,Nisalak A,Srikiatkhachorn A,Green S,Stephens HA,Rothman AL,Mathew A

更新日期：2014-01-01 00:00:00

abstract：:Myelin oligodendrocyte glycoprotein (MOG), a minor protein of the central nervous system myelin, is recognized as a potential target in multiple sclerosis and neuromyelitis optica. The extracellular domain of MOG is commonly used in a wide range of mouse strains and other animals to induce experimental autoimmune ence...

journal_title：Immunology

authors： Delarasse C,Smith P,Baker D,Amor S

更新日期：2013-12-01 00:00:00

abstract：:Allergic diseases are frequently exacerbated between midnight and early morning, suggesting a role for the biological clock. Mast cells (MC) and eosinophils are the main effector cells of allergic diseases and some MC-specific or eosinophil-specific markers, such as tryptase or eosinophil cationic protein, exhibit cir...

journal_title：Immunology

authors： Baumann A,Gönnenwein S,Bischoff SC,Sherman H,Chapnik N,Froy O,Lorentz A

更新日期：2013-12-01 00:00:00

abstract：:The mammalian target of rapamycin (mTOR) pathway is an important integrator of nutrient-sensing signals in all mammalian cells, and acts to coordinate the cell proliferation with the availability of nutrients such as glucose, amino acids and energy (oxygen and ATP). A large part of the immune response depends on the p...

journal_title：Immunology

authors： Cobbold SP

更新日期：2013-12-01 00:00:00

abstract：:In many types of tumours, especially pancreatic adenocarcinoma, miR-301a is over-expressed. This over-expression results in negative regulation of the target gene of miR-301a, the nuclear factor-κB (NF-κB) repressing factor (NKRF), increasing the activation of NF-κB and production of NF-κB-responsive pro-inflammatory ...

journal_title：Immunology

authors： Huang L,Liu Y,Wang L,Chen R,Ge W,Lin Z,Zhang Y,Liu S,Shan Y,Lin Q,Jiang M

更新日期：2013-11-01 00:00:00

abstract：:A sudden upsurge of fever cases with joint pain was observed in the outpatient department, Community Health Centre, Rangat during July-August 2010 in Rangat Middle Andaman, India. The aetiological agent responsible for the outbreak was identified as chikungunya virus (CHIKV), by using RT-PCR and IgM ELISA. The study i...

journal_title：Immunology

authors： Chaaithanya IK,Muruganandam N,Anwesh M,Rajesh R,Ghosal SR,Kartick C,Prasad KN,Muthumani K,Vijayachari P

更新日期：2013-10-01 00:00:00

abstract：:Anti-Gal is the most abundant natural antibody in humans, constituting ~ 1% of immunoglobulins. Anti-Gal is naturally produced also in apes and Old World monkeys. The ligand of anti-Gal is a carbohydrate antigen called the 'α-gal epitope' with the structure Galα1-3Galβ1-4GlcNAc-R. The α-gal epitope is present as a maj...

journal_title：Immunology

authors： Galili U

更新日期：2013-09-01 00:00:00

abstract：:Haptoglobin (Hp), a major acute-phase plasma protein, has been found in arthritic synovial fluid (SF). However, the function and structural modifications of Hp in arthritic SF are unknown. To investigate in vivo generation of modified Hp associated with inflammatory disease, we examined a new Hp isoform in SF from pat...

journal_title：Immunology

authors： Park HJ,Oh MK,Kim NH,Cho ML,Kim IS

更新日期：2013-09-01 00:00:00

abstract：:The current study sought to delineate the gene expression profile of the host response in the caecum and colon during acute infection with Clostridium difficile in a mouse model of infection, and to investigate the nature of the unfolded protein response in this process. The infected mice displayed a significant up-re...

journal_title：Immunology

authors： Sadighi Akha AA,Theriot CM,Erb-Downward JR,McDermott AJ,Falkowski NR,Tyra HM,Rutkowski DT,Young VB,Huffnagle GB

更新日期：2013-09-01 00:00:00

abstract：:We identified CD8(+)  CD122(+) regulatory T cells (CD8(+)  CD122(+) Treg cells) and reported their importance in maintaining immune homeostasis. The absence of CD8(+)  CD122(+) Treg cells has been shown to lead to severe systemic autoimmunity in several mouse models, including inflammatory bowel diseases and experimen...

journal_title：Immunology

authors： Okuno Y,Murakoshi A,Negita M,Akane K,Kojima S,Suzuki H

更新日期：2013-07-01 00:00:00

abstract：:Activation of naive CD8(+) T cells in the presence of interleukin-4 modulates their CD8 co-receptor expression and functional differentiation, resulting in the generation of CD8(low) cells that produce type 2 cytokines and display poor cytolytic and anti-tumour activity. Although this CD8(low) phenotype becomes stable...

journal_title：Immunology

authors： Olver S,Apte SH,Baz A,Kelso A,Kienzle N

更新日期：2013-06-01 00:00:00

abstract：:Interleukin-2 (IL-2) is a mainstay for current immunotherapeutic protocols but its usefulness in patients is reduced by severe toxicities and because IL-2 facilitates regulatory T (Treg) cell development. IL-21 is a type I cytokine acting as a potent T-cell co-mitogen but less efficient than IL-2 in sustaining T-cell ...

journal_title：Immunology

authors： Battaglia A,Buzzonetti A,Baranello C,Fanelli M,Fossati M,Catzola V,Scambia G,Fattorossi A

更新日期：2013-05-01 00:00:00

abstract：:Phagocytes such as dendritic cells (DC) and macrophages employ phagocytosis to take up pathogenic bacteria into phagosomes, digest the bacteria and present the bacteria-derived peptide antigens to the adaptive immunity. Hence, efficient antigen presentation depends greatly on a well-regulated phagocytosis process. Lip...

journal_title：Immunology

authors： Chua RY,Wong SH

更新日期：2013-05-01 00:00:00

abstract：:Bile acids (BAs) play important roles not only in lipid metabolism, but also in signal transduction. TGR5, a transmembrane receptor of BAs, is an immunomodulative factor, but its detailed mechanism remains unclear. Here, we aimed to delineate how BAs operate in immunological responses via the TGR5 pathway in human mon...

journal_title：Immunology

authors： Yoneno K,Hisamatsu T,Shimamura K,Kamada N,Ichikawa R,Kitazume MT,Mori M,Uo M,Namikawa Y,Matsuoka K,Sato T,Koganei K,Sugita A,Kanai T,Hibi T

更新日期：2013-05-01 00:00:00

abstract：:Immunoregulatory CD4(-)  CD8(-) (double-negative; DN) T cells exhibit a unique antigen-specific mode of suppression, yet the ontogeny of DN T cells remains enigmatic. We have recently shown that 3A9 T-cell receptor (TCR) transgenic mice bear a high proportion of immunoregulatory 3A9 DN T cells, facilitating their stud...

journal_title：Immunology

authors： Dugas V,Chabot-Roy G,Beauchamp C,Guimont-Desrochers F,Hillhouse EE,Liston A,Lesage S

更新日期：2013-05-01 00:00:00

abstract：:Compared with adults, the circulating Vγ2Vδ2 T-cell population in cord blood is present at low levels and does not show the strong bias for Vγ2-Jγ1.2 rearrangements. These features may be a result of limited exposure to stimulatory phosphoantigens, lack of T-cell-derived interleukin-2 (IL-2) or both. In cord blood mon...

journal_title：Immunology

authors： Cairo C,Sagnia B,Cappelli G,Colizzi V,Leke RG,Leke RJ,Pauza CD

更新日期：2013-04-01 00:00:00

abstract：:Sialoadhesin (Sn, also known as Siglec-1 and CD169) is a macrophage-restricted cell surface receptor that is conserved across mammals. Sn is a member of the sialic acid-binding IgG-like lectin (Siglec) family of proteins characterized by affinity to specifically sialylated ligands, and under normal conditions is expre...

journal_title：Immunology

authors： O'Neill AS,van den Berg TK,Mullen GE

更新日期：2013-03-01 00:00:00

abstract：:The tumour microenvironment is complex containing not only neoplastic cells but also a variety of host cells. The heterogeneous infiltrating immune cells include subsets of cells with opposing functions, whose activities are mediated either directly or through the cytokines they produce. Systemic delivery of cytokines...

journal_title：Immunology

authors： Gerber SA,Sorensen EW,Sedlacek AL,Lim JY,Skrombolas D,Frelinger JG,Lord EM

更新日期：2013-03-01 00:00:00

abstract：:Environmental factors have significant effects on the development of autoimmune diseases. The ligand-activated transcription factor aryl hydrocarbon receptor (AHR) is controlled by endogenous and environmental small molecules. Hence, AHR provides a molecular pathway by which endogenous and environmental signals can in...

journal_title：Immunology

authors： Quintana FJ

更新日期：2013-03-01 00:00:00

abstract：:Tumour-associated macrophages (TAMs) represent a predominant population of inflammatory cells that present in solid tumours. TAMs are mostly characterized as alternatively activated M2-like macrophages and are known to orchestrate nearly all stages of tumour progression. Experimental investigations indicate that TAMs ...

journal_title：Immunology

authors： Tang X,Mo C,Wang Y,Wei D,Xiao H

更新日期：2013-02-01 00:00:00

abstract：:It is now well accepted that sex hormones have immunoregulatory activity and may prevent exacerbations in multiple sclerosis during pregnancy. Our previous studies demonstrated that oestrogen (17β-oestradiol; E(2) ) protection against experimental autoimmune encephalomyelitis (EAE) is mediated mainly through oestrogen...

journal_title：Immunology

authors： Bodhankar S,Vandenbark AA,Offner H

更新日期：2012-12-01 00:00:00

abstract：:Natural killer (NK) cells have a specialized function in peripheral organs, which is determined by the organ-specific niches. We have attempted to explore whether lung NK cells display a particular phenotype according to their function in the unique pulmonary environment in health or during respiratory infection in mi...

journal_title：Immunology

authors： Wang J,Li F,Zheng M,Sun R,Wei H,Tian Z

更新日期：2012-09-01 00:00:00

abstract：:The discovery of host-encoded gene products that sense molecular patterns in infectious microbes, and the demonstration of their role in triggering innate and adaptive immune responses, has been a key milestone in our understanding of immunology. Twenty-three years after Janeway first outlined the fundamental concepts...

journal_title：Immunology

authors： Browne EP

更新日期：2012-08-01 00:00:00

abstract：:The aim of this study is to investigate the clinical significance of the ratio between interleukin-17 (IL-17) secreting cell and FOXP3-positive regulatory T cell (FOXP3(+) Treg) infiltration in renal allograft tissues with acute T-cell-mediated rejection (ATCMR). Fifty-six patients with biopsy-proven ATCMR were includ...

journal_title：Immunology

authors： Chung BH,Oh HJ,Piao SG,Hwang HS,Sun IO,Choi SR,Park HS,Choi BS,Choi YJ,Park CW,Kim YS,Cho ML,Yang CW

更新日期：2012-07-01 00:00:00

abstract：:Class switching and plasma cell differentiation occur at a high level within all mucosa-associated lymphoid tissues. The different classes of membrane immunoglobulin heavy chains are associated with the Igα/Igβ heterodimer within the B-cell receptor (BCR). Whether BCR isotypes convey specific signals adapted to the co...

journal_title：Immunology

authors： Amin R,Carrion C,Decourt C,Pinaud E,Cogné M

更新日期：2012-05-01 00:00:00

abstract：:We have previously reported that the 20-mer peptide p2340 (amino acids 2340-2359), of human thyroglobulin (Tg) has the unique feature that it causes experimental autoimmune thyroiditis (EAT) in mouse strains bearing high-responder (HR) or low-responder (LR) MHC haplotypes in Tg-induced EAT. In this study, we have empl...

journal_title：Immunology

authors： Hatzioannou A,Alevizaki M,Carayanniotis G,Lymberi P

更新日期：2012-03-01 00:00:00

abstract：:Cells of the female reproductive tract (FRT) can present antigen to naive and memory T cells. However, the effects of oestrogen, known to modulate immune responses, on antigen presentation in the FRT remain undefined. In the present study, DO11.10 T-cell antigen receptor transgenic mice specific for the class II MHC-r...

journal_title：Immunology

authors： Ochiel DO,Rossoll RM,Schaefer TM,Wira CR

更新日期：2012-01-01 00:00:00

abstract：:Studies have demonstrated that the anti-tumour effect of natural killer (NK) cells is successful for patients with several cancers. Although interleukin-32 (IL-32) is endogenously expressed in NK cells, cytolytic function of NK cells against cancer cells has not been fully demonstrated. In the present study, we found ...

journal_title：Immunology

authors： Park MH,Song MJ,Cho MC,Moon DC,Yoon DY,Han SB,Hong JT

更新日期：2012-01-01 00:00:00

abstract：:Norovirus (NoV) -derived virus-like particles (VLPs) resemble empty shells of the virus and NoV P-particles contain only protruding domains of the NoV capsid. Both NoV-derived subviral particles show similar functionality and antigenicity in vitro and are considered to be potential vaccine candidates against NoV gastr...

journal_title：Immunology

authors： Tamminen K,Huhti L,Koho T,Lappalainen S,Hytönen VP,Vesikari T,Blazevic V

更新日期：2012-01-01 00:00:00

abstract：:Over the past 10 years we have made great strides in our understanding of T helper cell differentiation, expansion and effector functions. Within the context of T helper type 2 (Th2) cell development, novel innate-like cells with the capacity to secrete large amounts of interleukin-5 (IL-5), IL-13 and IL-9 as well as ...

journal_title：Immunology

authors： Okoye IS,Wilson MS

更新日期：2011-12-01 00:00:00

abstract：:BLT mice, constructed by surgical implantation of human fetal thymus-liver tissues and intravenous delivery of autologous CD34+ haematopoietic stem cells into adult non-obese diabetic/severe combined immunodeficiency mice, were evaluated for vaccine-induced humoral immune responses. Following engraftment, these mice d...

journal_title：Immunology

authors： Biswas S,Chang H,Sarkis PT,Fikrig E,Zhu Q,Marasco WA

更新日期：2011-12-01 00:00:00

abstract：:The intestinal epithelium is rich in γδ T cells and the gut is a site of residence for a wide variety of pathogens, including nematodes. Although CD4+ T-cell receptor (TCR) -αβ+ T helper type 2 T cells are essential for the expulsion of intestinal nematodes, little information is available on the function of γδ T cell...

journal_title：Immunology

authors： Inagaki-Ohara K,Sakamoto Y,Dohi T,Smith AL

更新日期：2011-12-01 00:00:00

abstract：:Typhoid fever is a persistent infection caused by host-adapted Salmonella strains adept at circumventing immune-mediated host defences. Given the importance of T cells in protection, the culling of activated CD4+ T cells after primary infection has been proposed as a potential immune evasion strategy used by this path...

journal_title：Immunology

authors： Ertelt JM,Johanns TM,Mysz MA,Nanton MR,Rowe JH,Aguilera MN,Way SS

更新日期：2011-12-01 00:00:00

abstract：:Studies in long-term non-progressors (LTNP) have suggested that the quality of the CD8(+) response may involve protective human leucocyte antigen (HLA) class I alleles. However, studies examining the expansion ability of different functional CD8(+) T cells and their association with HLA class I alleles are lacking. LT...

journal_title：Immunology

authors： López M,Peris A,Soriano V,Lozano S,Vicario JL,Rallón NI,Restrepo C,Benito JM

更新日期：2011-11-01 00:00:00

abstract：:Human β-defensin 3 (hBD-3) activates antigen-presenting cells through Toll-like receptors (TLRs) 1/2. Several TLR1/2 agonists have been identified but little is known about how they might differentially affect cellular activation. We compared the effects of hBD-3 with those of another TLR1/2 agonist, Pam(3) CSK(4) , i...

journal_title：Immunology

authors： Funderburg NT,Jadlowsky JK,Lederman MM,Feng Z,Weinberg A,Sieg SF

更新日期：2011-10-01 00:00:00

abstract：:Chronic antigenic stimulation leads to gradual accumulation of late-differentiated, antigen-specific, oligoclonal T cells, particularly within the CD8(+) T-cell compartment. They are characterized by critically shortened telomeres, loss of CD28 and/or gain of CD57 expression and are defined as either CD8(+) CD28(-) or...

journal_title：Immunology

authors： Strioga M,Pasukoniene V,Characiejus D

更新日期：2011-09-01 00:00:00

abstract：:CD248 (endosialin) is a transmembrane glycoprotein that is dynamically expressed on pericytes and fibroblasts during tissue development, tumour neovascularization and inflammation. Its role in tissue remodelling is associated with increased stromal cell proliferation and migration. We show that CD248 is also uniquely ...

journal_title：Immunology

authors： Hardie DL,Baldwin MJ,Naylor A,Haworth OJ,Hou TZ,Lax S,Curnow SJ,Willcox N,MacFadyen J,Isacke CM,Buckley CD

更新日期：2011-07-01 00:00:00

abstract：:The functional avidity of a cytotoxic T lymphocyte (CTL) is known to be a critical determinant of the efficacy with which it clears pathogens. High avidity cells, which are by definition highly sensitive to peptide antigen, are superior for elimination of viruses and tumours. Our studies have established the ability o...

journal_title：Immunology

authors： Sharma SK,Alexander-Miller MA

更新日期：2011-07-01 00:00:00

abstract：:Anti-CD20 monoclonal antibodies are promising for the treatment of B-cell malignancies such as chronic lymphocytic leukaemia and autoimmune diseases where auto-antibodies play an important role. Anti-CD20 such as rituximab (RTX) mediates B-cell depletion through mechanisms such as complement-mediated cytotoxicity and ...

journal_title：Immunology

authors： Pedersen AE,Jungersen MB,Pedersen CD

更新日期：2011-06-01 00:00:00